From the Department of Pharmacy & Radboud Institute of Health Sciences (RIHS), Radboud university medical center, Nijmegen, the Netherlands.
Department of Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.
Pediatr Infect Dis J. 2018 Oct;37(10):1008-1010. doi: 10.1097/INF.0000000000001964.
In this multicenter pharmacokinetic study in HIV-infected children (6-12 years of age), we validated the approved once-daily darunavir/ritonavir dosing recommendations. The geometric mean darunavir area under the plasma concentration-time curve was 63.1 h·mg/L, substantially lower than the mean value observed in adults. However, all trough levels were adequate, and short-term virologic outcome was good. These data support the use of the darunavir/ritonavir once-daily dosing recommendations.
在这项多中心药代动力学研究中，我们验证了已批准的每日一次的达芦那韦/利托那韦剂量推荐方案。HIV 感染儿童（6-12 岁）的几何平均达芦那韦血药浓度-时间曲线下面积为 63.1 小时·mg/L，明显低于成人观察到的平均值。然而，所有谷浓度均足够，短期病毒学结果良好。这些数据支持达芦那韦/利托那韦每日一次的剂量推荐方案的使用。
