Aragno R, Bettini V, Bruni G, Mayellaro F, Ton P
Acta Vitaminol Enzymol. 1985;7(3-4):239-48.
It is known that the bioflavonoids as the Ca++ have an enhancing effect on the transmitter release in different cholinergic nerve-endings. For this reason, it is seemed interesting to study the influence of the separately tested 4-methylesculetin or associated with the ascorbic acid and comparatively the Ca++ concentration increase on the isolated rat stomach response by electrical transmural stimulation achieved in presence or absence of hexamethonium. Both the 4-methylesculetin and the ascorbic acid have always increased the response of the preparation submitted to electrical transmural stimulation. The 4-methylesculetin effect resulted particularly strong if the substance was employed with the ascorbic acid. The enhancing effect of the 4-methylesculetin, obtained with or without the ascorbic acid, is resulted comparatively lesser in presence of hexamethonium. On the basis of the evident analogy between the 4-methylesculetin effects and the ones determined by the increased Ca++ concentration, it can be supposed that the bioflavonoid facilitates the transmitter release in the pre- and postganglionic nerve-endings. The results here reported, confirm other previous observations accomplished on different cholinergic nerve-endings and could substain the hypothesis according to which the 4-methylesculetin increase the Ca++ transport through the biological membranes.
众所周知，生物类黄酮与钙离子一样，对不同胆碱能神经末梢的递质释放有增强作用。因此，研究单独测试的4-甲基七叶亭或与抗坏血酸联合使用时，以及相对地钙离子浓度增加时，在有无六甲铵存在的情况下通过电透壁刺激对离体大鼠胃反应的影响，似乎很有趣。4-甲基七叶亭和抗坏血酸总是会增加接受电透壁刺激的标本的反应。如果该物质与抗坏血酸一起使用，4-甲基七叶亭的效果尤为明显。在有六甲铵存在的情况下，无论有无抗坏血酸，4-甲基七叶亭的增强作用相对较小。基于4-甲基七叶亭的作用与钙离子浓度增加所产生的作用之间明显的相似性，可以推测生物类黄酮促进节前和节后神经末梢的递质释放。这里报道的结果证实了先前在不同胆碱能神经末梢上完成的其他观察结果，并支持4-甲基七叶亭增加钙离子通过生物膜转运的假说。
