[在连苯三酚存在的情况下，4-甲基七叶亭对离体冠状动脉段对肾上腺素反应的影响]

[Influence of 4-methylesculetol on the response of segments of isolated coronary arteries to adrenaline, in presence of pyrogallol].

作者信息

Bettini V, Baraldi S, Calcagno A, Legrenzi E, Mayellaro F, Martino R

出版信息

Acta Vitaminol Enzymol. 1981;3(4):236-43.

Abstract

The adrenaline (AD) induced relaxation in the smooth muscle is increased by bioflavonoids, possibly via cathecol-0-methyltransferase (COMT) inhibition. In order to test this hypothesis, we studied the influence of 4-methylesculetin (4-Me), alone or associated with ascorbic acid, on the response of isolated coronary strips to AD, in the presence of pyrogallol. Both 4-Me being enhanced by the addition of ascorbic acid. The effects were reduced or abolished in the presence off pyrogallol, a well known COMT inhibitor. It is concluded that 4-Me inhibits COMT, as other bioflavonoids.

摘要

生物类黄酮可能通过抑制儿茶酚 - O - 甲基转移酶（COMT）来增强肾上腺素（AD）引起的平滑肌舒张作用。为了验证这一假设，我们研究了在焦性没食子酸存在的情况下，4 - 甲基七叶亭（4 - Me）单独或与抗坏血酸联合使用对离体冠状动脉条对AD反应的影响。添加抗坏血酸可增强4 - Me的作用。在已知的COMT抑制剂焦性没食子酸存在时，这些作用减弱或消失。结论是，与其他生物类黄酮一样，4 - Me可抑制COMT。

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Acta Vitaminol Enzymol. 1981;3(4):236-43.

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