人类唾液正常矿物质组成的生理时相特征。

Chronophysiological features of the normal mineral composition of human saliva.

机构信息

KhimServis LLC, 4/2, Lugovaya str., Skolkovo Innovation Center, Moscow, 143026, Russia; Chair of Chemical Technology and Biotechnology, Omsk State Technical University, 11, Prospect Mira, Omsk, 644050, Russia.

KhimServis LLC, 4/2, Lugovaya str., Skolkovo Innovation Center, Moscow, 143026, Russia; Chair of Oncology with Radiotherapy, Omsk State Medical Academy, 12, Lenina str., Omsk, 644099, Russia.

出版信息

Arch Oral Biol. 2017 Oct;82:286-292. doi: 10.1016/j.archoralbio.2017.06.024. Epub 2017 Jun 24.

DOI:10.1016/j.archoralbio.2017.06.024

PMID:28686983

Abstract

BACKGROUND

The high rate of changes in the composition of saliva can be used for the monitoring of various biorhythms in order to study the physiological characteristics of the human body.

RESEARCH OBJECTIVE

The study of the dynamics of the near-24-h mineral composition of saliva in men and women.

METHODS

The study involved 20 men and 20 women, age 23.1±0.9years. Saliva samples were collected every 3h during the day within 10min. The mineral composition of saliva was defined by the capillary electrophoresis technique. The cross-group differences were evaluated using the non-parametric criterion.

RESULTS

It was shown that the maximum values of the mineralizing capacity fall to 7-8 a.m. and 18-19p.m., which is due to the change in the rate of saliva secretion. The near-24-h dynamics of the saliva pH practically coincides with the dynamics of the Ca/P ratio; there are evident maxima at 9:00 am and 15-18p.m. The values of the Na/K ratio are out of phase with the Ca/P ratio. There is one maximum, corresponding to 3 am in the night, and one minimum at 12-13p.m., which is due to a decreased level of sodium and increased potassium concentration. Statistically valid differences between men and women in pH (p<0.001), concentrations of inorganic phosphorus (p<0.001), as well as Ca/P coefficient (p=0.011) were identified.

CONCLUSION

The dynamics of the studied parameters during 24h is characterized by pronounced intervals.

摘要

背景

唾液组成的高变化率可用于监测各种生物节律，以研究人体的生理特征。

研究目的

研究男性和女性唾液近 24 小时矿物质组成的动态变化。

方法

本研究纳入了 20 名年龄为 23.1±0.9 岁的男性和 20 名女性。每天白天每 3 小时采集 10 分钟内的唾液样本。采用毛细管电泳技术定义唾液的矿物质组成。使用非参数标准评估组间差异。

结果

结果表明，最大矿化能力值出现在早上 7-8 点和晚上 6-7 点，这是由于唾液分泌率的变化所致。唾液 pH 的近 24 小时动态与 Ca/P 比值的动态基本一致；早上 9 点和下午 3-6 点有明显的峰值。Na/K 比值与 Ca/P 比值不同步。有一个最大值对应夜间 3 点，一个最小值对应下午 12-1 点，这是由于钠离子水平降低和钾离子浓度增加所致。在 pH（p<0.001）、无机磷浓度（p<0.001）以及 Ca/P 系数（p=0.011）方面，男女之间存在具有统计学意义的差异。