髓源性抑制细胞调节B细胞反应。
Myeloid-derived suppressor cells modulate B-cell responses.
作者信息
Lelis Felipe J N, Jaufmann Jennifer, Singh Anurag, Fromm Katja, Teschner Annkathrin Chiara, Pöschel Simone, Schäfer Iris, Beer-Hammer Sandra, Rieber Nikolaus, Hartl Dominik
机构信息
Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tuebingen, Tuebingen, Germany; Department of Pediatrics, Department of Infectious Diseades, Boston Children's Hospital, Harvard Medical School,300 Longwood Avenue, Boston, MA 02115, USA.
Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA, University of Tuebingen, 72074, Tuebingen, Germany.
出版信息
Immunol Lett. 2017 Aug;188:108-115. doi: 10.1016/j.imlet.2017.07.003. Epub 2017 Jul 4.
Myeloid-derived suppressor cells (MDSCs) are key regulators of adaptive immunity by suppressing T-cell functions. However, their potential action on or interaction with B cells remained poorly understood. Here we demonstrate that human polymorphonuclear MDSCs differentially modulate B-cell function by suppressing B-cell proliferation and antibody production. We further demonstrate that this MDSC-mediated effect is cell contact dependent and involves established mediators such as arginase-1, nitric oxide (NO), reactive oxygen species (ROS) as well as B-cell death. Collectively, our studies provide novel evidence that human MDSCs modulate B cells, which could have future implications for immunotherapy approaches.
髓源性抑制细胞（MDSCs）是通过抑制T细胞功能来调节适应性免疫的关键调节因子。然而，它们对B细胞的潜在作用或与B细胞的相互作用仍知之甚少。在此，我们证明人类多形核MDSCs通过抑制B细胞增殖和抗体产生来差异性地调节B细胞功能。我们进一步证明，这种MDSC介导的效应依赖于细胞接触，并涉及精氨酸酶-1、一氧化氮（NO）、活性氧（ROS）等既定介质以及B细胞死亡。总的来说，我们的研究提供了新的证据，表明人类MDSCs可调节B细胞，这可能对免疫治疗方法具有未来意义。
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