Shi Xiaoye, Cheng Xiangshu, Jiang Aimin, Shi Wenjie, Zhu Lingxuan, Mou Weiming, Glaviano Antonino, Liu Zaoqu, Cheng Quan, Lin Anqi, Wang Linhui, Luo Peng
Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China.
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Adv Sci (Weinh). 2024 Dec;11(47):e2403423. doi: 10.1002/advs.202403423. Epub 2024 Nov 7.
B cells are crucial component of humoral immunity, and their role in the tumor immune microenvironment (TME) has garnered significant attention in recent years. These cells hold great potential and application prospects in the field of tumor immunotherapy. Research has demonstrated that the TME can remodel various B cell functions, including proliferation, differentiation, antigen presentation, and antibody production, thereby invalidating the anti-tumor effects of B cells. Concurrently, numerous immune checkpoints (ICs) on the surface of B cells are upregulated. Aberrant B-cell IC signals not only impair the function of B cells themselves, but also modulate the tumor-killing effects of other immune cells, ultimately fostering an immunosuppressive TME and facilitating tumor immune escape. Blocking ICs on B cells is beneficial for reversing the immunosuppressive TME and restoring anti-tumor immune responses. In this paper, the intricate connection between B-cell ICs and the TME is delved into, emphasizing the critical role of targeting B-cell ICs in anti-tumor immunity, which may provide valuable insights for the future development of tumor immunotherapy based on B cells.
B细胞是体液免疫的关键组成部分，近年来它们在肿瘤免疫微环境（TME）中的作用备受关注。这些细胞在肿瘤免疫治疗领域具有巨大的潜力和应用前景。研究表明，TME可重塑多种B细胞功能，包括增殖、分化、抗原呈递和抗体产生，从而使B细胞的抗肿瘤作用失效。同时，B细胞表面的众多免疫检查点（IC）上调。异常的B细胞IC信号不仅损害B细胞自身的功能，还会调节其他免疫细胞的杀伤肿瘤作用，最终促进免疫抑制性TME的形成并促进肿瘤免疫逃逸。阻断B细胞上的IC有利于逆转免疫抑制性TME并恢复抗肿瘤免疫反应。本文深入探讨了B细胞IC与TME之间的复杂联系，强调了靶向B细胞IC在抗肿瘤免疫中的关键作用，这可能为基于B细胞的肿瘤免疫治疗的未来发展提供有价值的见解。
