Liang Shengxiang, Lin Yunjiao, Lin Bingbing, Li Jianhong, Liu Weilin, Chen Lidian, Zhao Shujun, Tao Jing
College of Physical Science and Technology, Zhengzhou University, Zhengzhou, China; College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China; Division of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China; Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing, China.
College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
J Stroke Cerebrovasc Dis. 2017 Sep;26(9):1953-1959. doi: 10.1016/j.jstrokecerebrovasdis.2017.06.018. Epub 2017 Jul 4.
To evaluate whether electro-acupuncture (EA) treatment at acupoints of Zusanli (ST 36) and Quchi (LI 11) could reduce motor impairments and enhance brain functional recovery in rats with ischemic stroke.
A rat model of middle cerebral artery occlusion (MCAO) was established. EA at ST 36 and LI 11was started at 24 hours (MCAO + EA group) after ischemic stroke. The nontreatment (MCAO) and sham-operated control (SC) groups were included as controls. The neurologic deficits of all groups were assessed by Zea Longa scores and the modified neurologic severity scores on 24 hours and 8 days after MCAO. To further investigate the effect of EA on infract volume and brain function, magnetic resonance imaging was used to estimate the brain lesion and brain neural activities of each group at 8 days after ischemic stroke.
Within 1 week after EA treatment, the neurologic deficits were significantly alleviated, and the cerebral infarctions were improved, including visual cortex, motor cortex, striatum, dorsal thalamus, and hippocampus. Furthermore, whole brain neural activities of auditory cortex, lateral nucleus group of dorsal thalamus, hippocampus, motor cortex, orbital cortex, sensory cortex, and striatum were decreased in MCAO group, whereas that of brain neural activities were increased after EA treatment, suggesting these brain regions are in accordance with the brain structure analysis.
EA at ST 36 and LI 11 could enhance the neural activity of motor function-related brain regions, including motor cortex, dorsal thalamus, and striatum in rats, which is a potential treatment for ischemia stroke.
评估电针足三里（ST 36）和曲池（LI 11）穴位是否能减轻缺血性脑卒中大鼠的运动功能障碍并促进脑功能恢复。
建立大鼠大脑中动脉闭塞（MCAO）模型。缺血性脑卒中后24小时开始对ST 36和LI 11进行电针治疗（MCAO + EA组）。将未治疗组（MCAO组）和假手术对照组（SC组）作为对照。在MCAO后24小时和8天，通过Zea Longa评分和改良神经功能缺损评分评估所有组的神经功能缺损。为进一步研究电针对梗死体积和脑功能的影响，在缺血性脑卒中后8天，使用磁共振成像评估每组的脑损伤和脑神经元活动。
电针治疗1周内，神经功能缺损明显减轻，脑梗死得到改善，包括视觉皮层、运动皮层、纹状体、背侧丘脑和海马体。此外，MCAO组听觉皮层、背侧丘脑外侧核群、海马体、运动皮层、眶额皮层、感觉皮层和纹状体的全脑神经元活动降低，而电针治疗后脑神经元活动增加，表明这些脑区与脑结构分析结果一致。
电针ST 36和LI 11可增强大鼠运动功能相关脑区（包括运动皮层、背侧丘脑和纹状体）的神经活动，这是缺血性脑卒中的一种潜在治疗方法。
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