Department of Pathology and Pathophysiology, Key Laboratory of Disease Proteomics of Zhejiang Province, School of Medicine, Chronic Disease Research Institute of School of Public Health, Zhejiang University, Hangzhou, 310058, China.
Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Protein Cell. 2018 Feb;9(2):207-215. doi: 10.1007/s13238-017-0442-2. Epub 2017 Jul 7.
Metabolic syndrome has become a global epidemic that adversely affects human health. Both genetic and environmental factors contribute to the pathogenesis of metabolic disorders; however, the mechanisms that integrate these cues to regulate metabolic physiology and the development of metabolic disorders remain incompletely defined. Emerging evidence suggests that SWI/SNF chromatin-remodeling complexes are critical for directing metabolic reprogramming and adaptation in response to nutritional and other physiological signals. The ATP-dependent SWI/SNF chromatin-remodeling complexes comprise up to 11 subunits, among which the BAF60 subunit serves as a key link between the core complexes and specific transcriptional factors. The BAF60 subunit has three members, BAF60a, b, and c. The distinct tissue distribution patterns and regulatory mechanisms of BAF60 proteins confer each isoform with specialized functions in different metabolic cell types. In this review, we summarize the emerging roles and mechanisms of BAF60 proteins in the regulation of nutrient sensing and energy metabolism under physiological and disease conditions.
代谢综合征已成为影响人类健康的全球性流行病。遗传和环境因素都促成了代谢紊乱的发病机制；然而，将这些线索整合起来调节代谢生理学和代谢紊乱发展的机制仍未完全确定。新出现的证据表明，SWI/SNF 染色质重塑复合物对于指导代谢重编程和对营养和其他生理信号的适应至关重要。ATP 依赖性 SWI/SNF 染色质重塑复合物包含多达 11 个亚基，其中 BAF60 亚基作为核心复合物与特定转录因子之间的关键连接。BAF60 亚基有三个成员，BAF60a、b 和 c。BAF60 蛋白的不同组织分布模式和调节机制赋予每个同工型在不同代谢细胞类型中具有特定的功能。在这篇综述中，我们总结了 BAF60 蛋白在生理和疾病条件下调节营养感应和能量代谢中的作用和机制。
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