Department of Nutrition, Food Sciences and Gastronomy, XaRTA, School of Pharmacy and Food Sciences, INSA, University of Barcelona, Barcelona, Spain.
Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
Mol Nutr Food Res. 2017 Nov;61(11). doi: 10.1002/mnfr.201600993. Epub 2017 Aug 28.
The effect of carotenoids from tomato juice (TJ) on inflammatory biomarkers was evaluated by performing a 4-week dose-response nutritional trial in a population at high cardiovascular risk.
An open, prospective, randomized, cross-over, and controlled clinical trial was carried out with 28 volunteers (mean age 69.7 ± 3.1 years; mean BMI 31.5 ± 3.6 kg/m ) at high cardiovascular risk, which were assigned to consume daily for 4 weeks in random order: 200 mL (LD) or 400 mL (HD) of TJ, or water as a control (C), with a 21-day wash-out period between each intervention. Blood samples were collected at baseline (B) and after each intervention. Endpoints included significant changes in plasmatic carotenoids, and adhesion molecules ICAM-1, and VCAM-1, as well as a tendency to decrease the chemokine IL-8. Compared to C, concentration of ICAM-1, and VCAM-1 were significantly lower (p ˂ 0.001), after each TJ intervention. Decreases were correlated remarkably with the trans-lycopene, while the other carotenoids present in TJ have presented a minor association or no association with changes in these molecules.
trans-Lycopene from TJ may attenuate the risk of cardiovascular disease by reducing the concentration of important inflammatory molecules related to atherosclerosis.
通过在心血管高风险人群中进行为期 4 周的剂量反应营养试验，评估番茄汁（TJ）中的类胡萝卜素对炎症生物标志物的影响。
一项开放性、前瞻性、随机、交叉对照临床试验在 28 名心血管高风险志愿者（平均年龄 69.7 ± 3.1 岁；平均 BMI 31.5 ± 3.6 kg/m ）中进行，这些志愿者被随机分配在 4 周内每天饮用：200 毫升（LD）或 400 毫升（HD）TJ，或水作为对照（C），每次干预之间有 21 天的洗脱期。在基线（B）和每次干预后采集血样。终点包括血浆类胡萝卜素、黏附分子 ICAM-1 和 VCAM-1 的显著变化，以及趋化因子 IL-8 有下降趋势。与 C 相比，每次 TJ 干预后 ICAM-1 和 VCAM-1 的浓度均显著降低（p ˂ 0.001）。下降与反式番茄红素显著相关，而 TJ 中存在的其他类胡萝卜素与这些分子的变化相关性较小或无相关性。
TJ 中的反式番茄红素可能通过降低与动脉粥样硬化相关的重要炎症分子的浓度来降低心血管疾病的风险。
