腹内侧前额叶体积在外倾思维与表达抑制的关联中的作用。
The role of ventromedial prefrontal cortex volume in the association of expressive suppression and externally oriented thinking.
机构信息
Department of Psychology, Shanghai Normal University, Shanghai 200234, China.
Department of Psychology, Shanghai Normal University, Shanghai 200234, China.
出版信息
J Affect Disord. 2017 Nov;222:112-119. doi: 10.1016/j.jad.2017.06.054. Epub 2017 Jun 27.
BACKGROUND
Studies have suggested that expressive suppression (ES) is linked to externally oriented thinking (EOT) through the ventromedial prefrontal cortex (vmPFC), and there are gender differences in their association. The present structural magnetic resonance imaging study was to investigate the neural bases of ES and EOT and their association in females versus males in a Chinese college sample.
METHODS
A total of 142 participants (83 females) were enrolled, and they completed the ES subscale of the Emotion Regulation Questionnaire, 20-item Toronto Alexithymia Scale, and anatomical scanning. Voxel-based morphometry, region of interest, and whole brain analyses with peak-level significance (family-wise error corrected at p < .05) were conducted to investigate the association of gray matter volume (GMV) variations with ES and EOT. A bootstrapping analysis was conducted to examine the role of vmPFC volume in the ES-EOT association.
RESULTS
The ES scores were positively linked to the GMV of the vmPFC in females and negatively related to right dorsolateral PFC volume in males. The EOT scores were positively correlated with the GMV of the vmPFC in females and supplementary motor area in males. Furthermore, vmPFC volume mediated the relationship between ES and EOT LIMITATIONS: The cross-sectional design limited causal conclusions.
CONCLUSIONS
The vmPFC may be the only neural base of ES and EOT and their association. In addition, these results were sex-specific.
背景
研究表明，表达抑制（ES）通过腹内侧前额叶皮层（vmPFC）与外向思维（EOT）有关，并且它们的关联存在性别差异。本结构磁共振成像研究旨在调查 ES 和 EOT 及其在女性与男性中的关联的神经基础。
方法
共纳入 142 名参与者（83 名女性），他们完成了情绪调节问卷的 ES 分量表、20 项多伦多述情障碍量表和解剖扫描。进行基于体素的形态计量学、感兴趣区域和全脑分析（采用 family-wise error 校正，p <.05），以调查灰质体积（GMV）变化与 ES 和 EOT 的关联。进行了 bootstrap 分析，以检验 vmPFC 体积在 ES-EOT 关联中的作用。
结果
女性的 ES 评分与 vmPFC 的 GMV 呈正相关，而男性的 ES 评分与右侧背外侧前额叶皮层的 GMV 呈负相关。女性的 EOT 评分与 vmPFC 的 GMV 呈正相关，而男性的 EOT 评分与辅助运动区的 GMV 呈正相关。此外，vmPFC 体积介导了 ES 和 EOT 之间的关系。
局限性
横断面设计限制了因果结论。
结论
vmPFC 可能是 ES 和 EOT 及其关联的唯一神经基础。此外，这些结果是性别特异性的。
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