Gaskill Cameron E, Kling Catherine E, Varghese Thomas K, Veenstra David L, Thirlby Richard C, Flum David R, Alfonso-Cristancho Rafael
Department of Surgery, University of Washington, Seattle, Washington; Surgical Outcomes Research Center, Department of Surgery, University of Washington, Seattle, Washington.
Department of Surgery, University of Washington, Seattle, Washington; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
J Surg Res. 2017 Jul;215:183-189. doi: 10.1016/j.jss.2017.03.067. Epub 2017 Apr 7.
Cigarette smoking increases the risk of postoperative complications nearly 2-fold. Preoperative smoking cessation programs may reduce complications as well as overall postoperative costs. We aim to create an economic evaluation framework to estimate the potential value of preoperative smoking cessation programs for patients undergoing elective colorectal surgery.
A decision-analytic model from the payer perspective was developed to integrate the costs and incidence of 90-day postoperative complications and readmissions for a cohort of patients undergoing elective colorectal surgery after a smoking cessation program versus usual care. Complication, readmission, and cost data were derived from a cohort of 534 current smokers and recent quitters undergoing elective colorectal resections in Washington State's Surgical Care and Outcomes Assessment Program linked to Washington State's Comprehensive Hospital Abstract Reporting System. Smoking cessation program efficacy was obtained from the literature. Sensitivity analyses were performed to account for uncertainty.
For a cohort of patients, the base case estimates imply that the total direct medical costs for patients who underwent a preoperative smoking cessation program were on average $304 (95% CI: $40-$571) lower per patient than those under usual care during the first 90 days after surgery. The model was most sensitive to the odds of recent quitters developing complications or requiring readmission, and smoking program efficacy.
A preoperative smoking cessation program is predicted to be cost-saving over the global postoperative period if the cost of the intervention is below $304 per patient. This framework allows the value of smoking cessation programs of variable cost and effectiveness to be determined.
吸烟会使术后并发症风险增加近两倍。术前戒烟计划可能会减少并发症以及降低术后总体成本。我们旨在创建一个经济评估框架,以估计术前戒烟计划对接受择期结直肠手术患者的潜在价值。
从支付方的角度开发了一个决策分析模型,以整合接受戒烟计划与常规护理的择期结直肠手术患者队列在术后90天并发症和再入院的成本及发生率。并发症、再入院和成本数据来自华盛顿州外科护理与结果评估计划中534名当前吸烟者和近期戒烟者的队列,该计划与华盛顿州综合医院摘要报告系统相关联。戒烟计划的疗效来自文献。进行敏感性分析以考虑不确定性。
对于一组患者,基础病例估计表明,接受术前戒烟计划的患者在术后前90天的人均直接医疗总成本比接受常规护理的患者平均低304美元(95%可信区间:40 - 571美元)。该模型对近期戒烟者发生并发症或需要再入院的几率以及戒烟计划的疗效最为敏感。
如果干预成本低于人均304美元,预计术前戒烟计划在整个术后期间可节省成本。该框架能够确定可变成本和有效性的戒烟计划的价值。