Wong Belinda Shu Ee, Hu Qidong, Baeg Gyeong Hun
Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 117594, Singapore.
Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 117594, Singapore.
Food Chem Toxicol. 2017 Nov;109(Pt 1):746-752. doi: 10.1016/j.fct.2017.07.006. Epub 2017 Jul 5.
The increasing application of nanoparticles in healthcare and consumer products has made them ever present in our lives. However, constant exposure to these nanoparticles has raised concerns regarding their adverse side effects on human health, signifying the great importance of nanotoxicity studies. Indeed, extensive in vitro and in vivo studies in this field have provided valuable insights into the potential cytotoxicity and genotoxicity induced by nanoparticles. Interestingly, there is a growing body of evidence that nanoparticles can also induce epigenetic changes. In particular, several studies have explored the alterations in DNA methylation patterns, histone modifications and miRNA expressions upon exposure to the different types of nanoparticles. In this review, we focused on the identified epigenetic modulations in nanoparticle-mediated toxicity, and proposed future challenges that remain to be addressed.
纳米颗粒在医疗保健和消费品中的应用日益广泛，这使得它们在我们的生活中无处不在。然而，持续接触这些纳米颗粒引发了人们对其对人类健康产生不良副作用的担忧，这凸显了纳米毒性研究的重要性。事实上，该领域广泛的体外和体内研究为纳米颗粒诱导的潜在细胞毒性和基因毒性提供了有价值的见解。有趣的是，越来越多的证据表明纳米颗粒也能诱导表观遗传变化。特别是，一些研究探讨了暴露于不同类型纳米颗粒后DNA甲基化模式、组蛋白修饰和miRNA表达的变化。在这篇综述中，我们重点关注了纳米颗粒介导的毒性中已确定的表观遗传调控，并提出了有待解决的未来挑战。
