Wang Yi, Ruan Fengkai, Zuo Zhenghong, He Chengyong
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Shenzhen Research Institute of Xiamen University, Xiamen University, Xiamen 361005, China.
Nanomaterials (Basel). 2022 Jan 25;12(3):389. doi: 10.3390/nano12030389.
With the increasing application of nanoparticles (NPs) in medical and consumer applications, it is necessary to ensure their safety. As mA (N-methyladenosine) RNA modification is one of the most prevalent RNA modifications involved in many diseases and essential biological processes, the relationship between nanoparticles and mA RNA modification for the modulation of these events has attracted substantial research interest. However, there is limited knowledge regarding the relationship between nanoparticles and mA RNA modification, but evidence is beginning to emerge. Therefore, a summary of these aspects from current research on nanoparticle-induced mA RNA modification is timely and significant. In this review, we highlight the roles of mA RNA modification in the bioimpacts of nanoparticles and thus elaborate on the mechanisms of nanoparticle-induced mA RNA modification. We also summarize the dynamic regulation and biofunctions of mA RNA modification. Moreover, we emphasize recent advances in the application perspective of nanoparticle-induced mA RNA modification in medication and toxicity of nanoparticles to provide a potential method to facilitate the design of nanoparticles by deliberately tuning mA RNA modification.
随着纳米颗粒（NPs）在医学和消费应用中的应用日益增加，确保其安全性变得十分必要。由于N⁶-甲基腺苷（mA）RNA修饰是参与许多疾病和重要生物学过程的最普遍的RNA修饰之一，纳米颗粒与mA RNA修饰之间在调节这些事件方面的关系已引起了大量研究兴趣。然而，关于纳米颗粒与mA RNA修饰之间的关系，目前了解有限，但相关证据已开始出现。因此，对当前纳米颗粒诱导的mA RNA修饰研究中的这些方面进行总结既及时又重要。在本综述中，我们强调了mA RNA修饰在纳米颗粒生物效应中的作用，并详细阐述了纳米颗粒诱导mA RNA修饰的机制。我们还总结了mA RNA修饰的动态调控和生物学功能。此外，我们着重介绍了纳米颗粒诱导的mA RNA修饰在药物治疗和纳米颗粒毒性应用方面的最新进展，旨在提供一种潜在方法，通过有意调节mA RNA修饰来促进纳米颗粒的设计。
