Uvarova L G, Zherdev V P, Neznamov G G, Khrulenko-Varnitskiĭ I O, Sigunova E A
Farmakol Toksikol. 1986 Jan-Feb;49(1):66-9.
Interaction between the clinical, EEG-effects and phenazepam concentration in the blood was studied in 111 patients with neurotic disorders after intake of the test drug dose (2 mg) administered singly and on the 14th day of the treatment. It was established that EEG changes commonly induced by benzodiazepines supervene primarily within the interval of 1 to 3 h after a single intake which correlates with the maximal degree of the tranquilizing, somnolent and myorelaxant drug action. It was demonstrated that the clinical and EEG-effects occur before attainment of the maximal phenazepam concentration and then become less potent, with preservation of the high blood drug level. Intake of the test dose during the treatment course is characterized, as compared with the effect of a single intake, by less marked clinical action of the drug and the lack of significant changes on the EEG and in the blood phenazepam concentration.
对111例神经症患者在单次服用试验药物剂量（2毫克）后以及治疗第14天，研究了临床症状、脑电图效应与血液中芬那西泮浓度之间的相互作用。结果表明，苯二氮䓬类药物通常引起的脑电图变化主要在单次服药后1至3小时内出现，这与药物最大程度的镇静、嗜睡和肌松作用相关。结果证明，临床症状和脑电图效应在芬那西泮达到最大浓度之前就已出现，随后作用减弱，但血液中的药物水平仍维持在较高水平。与单次服药的效果相比，在治疗过程中服用试验剂量的特点是药物的临床作用不太明显，脑电图和血液中芬那西泮浓度没有显著变化。
