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[安定药非那西泮单次及长期给药于患者时的药代动力学指标之间的相关性]

[Correlations between the pharmacokinetic indices of the tranquilizer fenazepam in single and long-term administration to patients].

作者信息

Zherdev V P, Aleksandrovskiĭ Iu A, Neznamov G G, Rudenko G M, Antokhin E A

出版信息

Farmakol Toksikol. 1987 Jan-Feb;50(1):81-5.

PMID:3556559
Abstract

A high degree of correlation between experimentally established and theoretically calculated constant concentrations of phenazepam was revealed in blood plasma of patients. Due to experimental findings the employment of a single-dose drug administration with regard to previously stated effective-dose interval during dosage build-up made possible estimating the maximum allowable individual dosage which should yield a good therapeutic result without side effects.

摘要

在患者血浆中发现,实验确定的和理论计算的芬那西泮恒定浓度之间存在高度相关性。基于实验结果,在剂量递增过程中,按照先前所述的有效剂量间隔采用单剂量给药,使得估算最大允许个体剂量成为可能,该剂量应能产生良好的治疗效果且无副作用。

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