大鼠唾液腺中四氢生物蝶呤和鸟苷三磷酸环化水解酶的发育
Development of tetrahydrobiopterin and GTP cyclohydrolase in salivary glands of rats.
作者信息
Katoh S, Sueoka T
出版信息
Int J Biochem. 1986;18(2):131-5. doi: 10.1016/0020-711x(86)90144-8.
A significant amount of 5,6,7,8-tetrahydrobiopterin (BH4), an essential cofactor of tyrosine hydroxylase, and the activity of GTP cyclohydrolase (GTP cycl), the first and rate-limiting enzyme in BH4 biosynthesis, were found in rat salivary glands, in which adrenergic transmitters are localized, from day 4 through 56 after birth. About 90 ng of BH4 per g wet weight were determined in the glands (submandibular and sublingual) of adult rats. The levels of them which were maintained from 2 weeks after birth up to the adult stage correlated with a previous finding in the maintenance of catecholamine concentration during the same stage in rat salivary glands.
在出生后第4天至56天的大鼠唾液腺中发现了大量的5,6,7,8-四氢生物蝶呤（BH4），它是酪氨酸羟化酶的一种必需辅因子，同时还发现了BH4生物合成过程中的首个限速酶——鸟苷三磷酸环化水解酶（GTP cycl）的活性。大鼠唾液腺中存在肾上腺素能递质。成年大鼠的腺体（下颌下腺和舌下腺）中每克湿重约含90纳克BH4。从出生后2周直至成年阶段，它们的水平保持稳定，这与之前在大鼠唾液腺同一阶段儿茶酚胺浓度维持情况的研究结果相关。
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