纹状体中的四氢生物蝶呤：在多巴胺神经末梢的定位及在儿茶酚胺合成中的作用。
Tetrahydrobiopterin in striatum: localization in dopamine nerve terminals and role in catecholamine synthesis.
作者信息
Levine R A, Miller L P, Lovenberg W
出版信息
Science. 1981 Nov 20;214(4523):919-21. doi: 10.1126/science.6117945.
PMID:6117945
Abstract
The hydroxylase cofactor, tetrahydrobiopterin, and its biosynthetic system are localized in dopaminergic nerve terminals in the striatum. This conclusion is based on the nearly equivalent loss of tyrosine hydroxylase and tetrahydrobiopterin and its initial biosynthetic enzyme, guanosine triphosphate cyclohydrolase, after injection of 6-hydroxydopamine into the substantia nigra. The role of the hydroxylase cofactor in the regulation of dopamine synthesis is reassessed.
摘要
羟化酶辅因子四氢生物蝶呤及其生物合成系统定位于纹状体中的多巴胺能神经末梢。这一结论基于在向黑质注射6-羟基多巴胺后，酪氨酸羟化酶、四氢生物蝶呤及其初始生物合成酶鸟苷三磷酸环化水解酶几乎同等程度的丧失。对羟化酶辅因子在多巴胺合成调节中的作用进行了重新评估。
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