四氢生物蝶呤和鸟苷-5'-三磷酸环水解酶的发育：大鼠脑和松果体中的差异模式。

The development of tetrahydrobiopterin and guanosine-5'-triphosphate cyclohydrolase: differential patterns in rat brain and pineal gland.

作者信息

Kapatos G, Kaufman S, Weller J L, Klein D C

出版信息

Brain Res. 1983 Jan 10;258(2):351-5. doi: 10.1016/0006-8993(83)91165-4.

Abstract

The developmental patterns of appearance of 5,6,7,8-tetrahydrobiopterin (BH4) and the first enzyme in BH4 biosynthesis, guanosine-5'-triphosphate cyclohydrolase (GTPcyc), were examined in rat brain and pineal gland. A parallel relationship between BH4 content and GTPcyc activity was evident in both tissues during development. In brain, the maximal content of BH4 and activity of GTPcyc was observed 2 days prior to, and 10 days after, birth. In contrast, both pineal BH4 content and GTPcyc activity became maximal postnatally. The influence of neural input on the developmental appearance of pineal BH4 was examined in rats that had been superior cervical ganglionectomized shortly after birth. It was found that this procedure did not alter the developmental appearance of BH4.

摘要

研究了大鼠脑和松果体中5,6,7,8-四氢生物蝶呤（BH4）的出现发育模式以及BH4生物合成中的第一种酶——鸟苷-5'-三磷酸环化水解酶（GTPcyc）。在发育过程中，两种组织中BH4含量与GTPcyc活性之间均存在明显的平行关系。在脑中，BH4的最大含量和GTPcyc的活性分别在出生前2天和出生后10天观察到。相比之下，松果体中BH4的含量和GTPcyc的活性在出生后达到最大值。对出生后不久进行了颈上神经节切除的大鼠，研究了神经输入对松果体BH4发育出现的影响。结果发现，该手术并未改变BH4的发育出现情况。