V Anupama K, Rao Purnima S, Adappa Sushma, Balanthimogru Prashantha, Mahabala Chakrapani
1 Resident, Department of Medicine, Kasturba Medical College, Manipal University, Mangalore, India.
2 Associate Professor, Department. of Pathology, Kasturba Medical College, Manipal University, Mangalore, India.
Trop Doct. 2017 Jul;47(3):217-221. doi: 10.1177/0049475516678478. Epub 2016 Nov 15.
Bone marrow aspirate examination is a gold standard to assess bone marrow iron stores. The correlation between serum ferritin and bone marrow iron has not been established in detail, as the cutoff value for iron stores have not been uniformly established. Ours was a cross-sectional study. Perl's Prussian blue stain was used to stain bone marrow, assessed by Gale's grading. Receiver operating characteristic curve analysis and Spearman's correlation coefficient calculated. Gale's grading revealed iron store deficiency in 26 and sufficiency in 13. Spearman's correlation coefficient of 0.90 showed a significant relation between serum ferritin and bone marrow iron stores. A serum ferritin of 228 pmol/L had high sensitivity and specificity for iron deficiency; our study suggests that this level be taken as the cutoff value to predict iron store deficiency in bone marrow.
骨髓穿刺检查是评估骨髓铁储备的金标准。由于铁储备的临界值尚未统一确定，血清铁蛋白与骨髓铁之间的相关性尚未详细确立。我们进行的是一项横断面研究。采用 Perl 普鲁士蓝染色法对骨髓进行染色，通过 Gale 分级进行评估。计算受试者工作特征曲线分析和 Spearman 相关系数。Gale 分级显示 26 例存在铁储备缺乏，13 例铁储备充足。Spearman 相关系数为 0.90，表明血清铁蛋白与骨髓铁储备之间存在显著关系。血清铁蛋白 228 pmol/L 对缺铁具有高敏感性和特异性；我们的研究表明，该水平可作为预测骨髓铁储备缺乏的临界值。
