Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
J Craniomaxillofac Surg. 2017 Sep;45(9):1458-1463. doi: 10.1016/j.jcms.2017.06.004. Epub 2017 Jun 10.
The CryoSeal FS System has been recently introduced as an automated device for the production of complete fibrin glue from autologous plasma, rather than from pool allogenic or cattle blood, to prevent viral infection and allergic reaction. We evaluated the effectiveness of complete autologous fibrin glue and polyglycolic acid (PGA) sheet wound coverings in mucosa defect oral surgery. Postoperative pain, scar contracture, ingestion, tongue dyskinesia, and postoperative bleeding were evaluated in 12 patients who underwent oral (including the tongue) mucosa excision, and received a PGA sheet and an autologous fibrin glue covering. They were compared with 12 patients who received a PGA sheet and commercial allogenic fibrin glue. All cases in the complete autologous fibrin glue group demonstrated good wound healing without complications such as local infection or incomplete cure. All evaluated clinical measures in this group were similar or superior to the commercial allogenic fibrin glue group. Coagulation and adhesion quality achieved with this method was comparable to that with a PGA sheet and commercial fibrin glue. Covering oral surgery wounds with complete autologous fibrin glue produced by an automated device was convenient, safe, and reduced the risk of viral infection and allergic reaction associated with conventional techniques.
CryoSeal FS 系统最近被引入作为一种自动化设备，用于从自体血浆而不是从同种异体或牛血中生产完整的纤维蛋白胶，以预防病毒感染和过敏反应。我们评估了完整的自体纤维蛋白胶和聚乙醇酸 (PGA) 片在口腔黏膜缺损手术中的有效性。12 例接受口腔（包括舌）黏膜切除术的患者接受 PGA 片和自体纤维蛋白胶覆盖物治疗，术后疼痛、瘢痕挛缩、吞咽、舌运动障碍和术后出血等情况进行评估，并与 12 例接受 PGA 片和商业同种异体纤维蛋白胶治疗的患者进行比较。在完全自体纤维蛋白胶组的所有病例中，均显示出良好的愈合，没有局部感染或愈合不全等并发症。该组的所有评估临床指标均与商业同种异体纤维蛋白胶组相似或更优。该方法达到的凝血和黏附质量与 PGA 片和商业纤维蛋白胶相当。使用自动化设备制备的完整自体纤维蛋白胶覆盖口腔手术伤口既方便又安全，降低了与传统技术相关的病毒感染和过敏反应的风险。
