Alaya R, Alaya Z, Nang M, Bouajina E
Service de rhumatologie, centre hospitalier Sud Francilien, 91100 Corbeil-Essonnes, France.
Service de rhumatologie, hôpital Farhat Hached, avenue Ibn El Jazzar, 4000 Sousse, Tunisie.
Rev Med Interne. 2018 Mar;39(3):185-191. doi: 10.1016/j.revmed.2017.05.010. Epub 2017 Jul 6.
Paget's disease of bone is the second most common metabolic bone disease after osteoporosis. Its pathogenesis is not yet clearly understood. Geographic distribution and epidemiological variations suggest a role of genetic and environmental factors in its pathophysiology. The frequency of the Paget's disease of bone increases with age. Its discovery can be fortuitous. Prognosis mainly depends on the occurrence of complications involving bones and joints, neurological, cardiovascular or metabolic systems. Treatment of symptomatic forms currently relies on bisphosphonates that have transformed its prognosis.
骨佩吉特病是仅次于骨质疏松症的第二常见的代谢性骨病。其发病机制尚未完全明确。地域分布和流行病学差异表明遗传和环境因素在其病理生理学中发挥作用。骨佩吉特病的发病率随年龄增长而增加。其发现可能是偶然的。预后主要取决于涉及骨骼和关节、神经、心血管或代谢系统的并发症的发生情况。目前，有症状形式的治疗依赖于双膦酸盐，这改变了其预后。
