Center for Bone Quality, Leiden University Medical Center, Leiden, The Netherlands.
Best Pract Res Clin Endocrinol Metab. 2018 Oct;32(5):657-668. doi: 10.1016/j.beem.2018.05.005. Epub 2018 May 26.
Paget's disease of bone is a focal disorder of bone remodelling that progresses slowly and leads to changes in the shape and size of affected bones and to skeletal, articular and vascular complications. In some parts of the world it is the second most common bone disorder after osteoporosis though in recent years its prevalence and severity appear to decrease. The disease is easily diagnosed and effectively treated but its pathogenesis remains incompletely understood.
佩吉特病是一种骨重建的局灶性疾病，其进展缓慢，导致受累骨骼的形状和大小发生变化，并引起骨骼、关节和血管并发症。在世界某些地区，它是继骨质疏松症之后第二常见的骨骼疾病，但近年来其患病率和严重程度似乎有所下降。该病易于诊断且治疗效果显著，但发病机制仍不完全清楚。
