Unit of Dermatology and Venereology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, Unit of Dermatology and Venereology, Karolinska University Hospital, Solna, Sweden.
Eur J Dermatol. 2017 Jun 1;27(S1):12-14. doi: 10.1684/ejd.2017.3040.
Wound healing is a fundamental physiological progress to keep the integrity of the skin. The transition from inflammation to proliferation is a critical step during skin wound repair process. Impairment of this transition has been known as a common dominator in the pathophysiology of chronic non-healing wounds. MicroRNAs (miRNAs) are short non-coding RNAs regulating gene expression. Emerging evidence has revealed that miRNAs play important roles in both normal skin wound healing and in the pathogenesis of chronic wounds. We focus on the miRNAs regulating the inflammation-proliferation transition during wound healing and propose that these miRNAs may be promising targets for development of more effective wound therapy.
伤口愈合是保持皮肤完整性的基本生理过程。从炎症到增殖的转变是皮肤伤口修复过程中的关键步骤。这种转变的损伤被认为是慢性难愈性伤口病理生理学的共同主导因素。微小 RNA（miRNA）是调节基因表达的短非编码 RNA。新出现的证据表明，miRNA 在正常皮肤伤口愈合和慢性伤口发病机制中都发挥着重要作用。我们专注于调节伤口愈合过程中炎症-增殖转变的 miRNA，并提出这些 miRNA 可能是开发更有效的伤口治疗方法的有前途的靶点。
