早期后去极化引起的组织和全器官水平的兴奋空间模式。

Vandersickel Nele, Van Nieuwenhuyse Enid, Seemann Gunnar, Panfilov Alexander V

Department of Physics and Astronomy, Ghent UniversityGhent, Belgium.

Institute for Experimental Cardiovascular Medicine, University Heart Center Freiburg · Bad Krozingen, Medical Center, University of FreiburgFreiburg, Germany.

Front Physiol. 2017 Jun 22;8:404. doi: 10.3389/fphys.2017.00404. eCollection 2017.

Early after depolarizations (EAD) occur in many pathological conditions, such as congenital or acquired channelopathies, drug induced arrhythmias, and several other situations that are associated with increased arrhythmogenicity. In this paper we present an overview of the relevant computational studies on spatial EAD dynamics in 1D, 2D, and in 3D anatomical models and discuss the relation of EADs to cardiac arrhythmias. We also discuss unsolved problems and highlight new lines of research in this area.

早后去极化（EAD）发生于许多病理状况下，如先天性或后天性离子通道病、药物诱导的心律失常以及其他一些与心律失常性增加相关的情况。在本文中，我们概述了在一维、二维和三维解剖模型中关于空间EAD动力学的相关计算研究，并讨论了EAD与心脏心律失常的关系。我们还讨论了未解决的问题，并突出了该领域新的研究方向。