模拟在半封闭管状栓子取出装置设计中的作用
The Role of Simulation in the Design of a Semi-Enclosed Tubular Embolus Retrieval.
作者信息
Gu Xuelian, Qi Yongxiang, Erdman Arthur, Li Zhonghua
机构信息
Shanghai Institute for Minimally Invasive Therapy, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China e-mail:
MicroPort Endovascular (Shanghai) Co., Ltd., 3399 Kangxin Road, Shanghai 201318, China.
出版信息
J Med Device. 2017 Jun;11(2):0210011-210017. doi: 10.1115/1.4036286. Epub 2017 May 3.
A numerical analysis of a semi-enclosed tubular mechanical embolus retrieval device (MERD) for the treatment of acute ischemic stroke (AIS) is presented. In this research, the finite element analysis (FEA) methodology is used to evaluate mechanical performance and provide suggestions for optimizing the geometric design. A MERD fabricated from nickel-titanium alloy (Nitinol) tubing is simulated and analyzed under complex in vivo loading conditions involving shape-setting, crimping, deployment, and embolus retrieval. As a result, the peak strain of the shape-setting procedure is proved to be safe for the device pattern. However, the MERD shows poor mechanical behavior after crimping into a catheter, because the peak crimping strain obtains a value of 12.1%. The delivery and deployment step demonstrates that the artery wall has little risk of serious injuries or rupture. In addition, the process of simulation of embolus retrieval and device system migration inside the cerebral artery lumen provides useful information during the design process.
本文介绍了一种用于治疗急性缺血性中风（AIS）的半封闭式管状机械取栓装置（MERD）的数值分析。在本研究中，采用有限元分析（FEA）方法来评估机械性能，并为优化几何设计提供建议。对由镍钛合金（Nitinol）管材制成的MERD在包括定形、压接、展开和取栓等复杂的体内加载条件下进行模拟和分析。结果表明，定形过程中的峰值应变对装置模式是安全的。然而，MERD在压接到导管后表现出较差的机械性能，因为峰值压接应变达到了12.1%。输送和展开步骤表明动脉壁受到严重损伤或破裂的风险很小。此外，在脑动脉腔内取栓和装置系统迁移的模拟过程为设计过程提供了有用信息。
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