Fishler Rami, Sznitman Josué
Department of Biomedical Engineering, Technion-Israel Institute of Technology.
Inhalation. 2017 Jun;11(3):21-25.
This article discusses a novel method to estimate aerodynamic particle size distributions (APSDs) of pharmaceutical aerosols through direct measurement of particle settling velocities using image-based analysis and particle tracking techniques. This simple, optical method provides accurate and fast measurements (approximately 1 minute) with few sources of bias due to specific device design choices or operation conditions. A proof-of-concept for the method is demonstrated by measuring APSDs for widely available commercial dry powder inhalers (DPIs), then comparing the results with previously published data from cascade impactors (CIs) and the Aerodynamic Particle Sizer (APS).
本文讨论了一种通过基于图像分析和粒子跟踪技术直接测量粒子沉降速度来估算药物气雾剂的空气动力学粒径分布（APSD）的新方法。这种简单的光学方法提供了准确且快速的测量（约1分钟），由于特定的设备设计选择或操作条件，偏差来源很少。通过测量市售干粉吸入器（DPI）的APSD，然后将结果与先前发表的级联撞击器（CI）和空气动力学粒径分析仪（APS）的数据进行比较，证明了该方法的概念验证。
