Vilhardt H, Krarup T, Holst J J, Bie P
J Endocrinol. 1986 Feb;108(2):293-8. doi: 10.1677/joe.0.1080293.
Injections and infusions of oxytocin into conscious dogs caused an increase in plasma concentrations of glucose, insulin and glucagon. When blood glucose was clamped at a raised level the injection of oxytocin still increased insulin and glucagon concentrations in plasma. Infusion of somatostatin suppressed plasma concentrations of glucagon and insulin but did not prevent oxytocin-induced increments in blood glucose. Injection of oxytocin still caused a marked release of glucagon, whereas the insulin response was greatly diminished. When endogenous insulin and glucagon secretion was suppressed by infusion of somatostatin and glucose levels were stabilized by concomitant infusions of glucagon and insulin, injections of oxytocin did not alter blood glucose concentrations. It is concluded that the increase in blood glucose following the administration of oxytocin is secondary to the release of glucagon and that oxytocin exerts a direct stimulatory effect on glucagon and possibly insulin secretion.
向清醒的狗体内注射和输注催产素会导致血浆中葡萄糖、胰岛素和胰高血糖素浓度升高。当血糖被钳定在升高水平时，注射催产素仍会增加血浆中胰岛素和胰高血糖素的浓度。输注生长抑素可抑制血浆中胰高血糖素和胰岛素的浓度，但不能阻止催产素诱导的血糖升高。注射催产素仍会导致胰高血糖素的显著释放，而胰岛素反应则大大减弱。当通过输注生长抑素抑制内源性胰岛素和胰高血糖素分泌，并通过同时输注胰高血糖素和胰岛素使血糖水平稳定时，注射催产素不会改变血糖浓度。得出的结论是，催产素给药后血糖升高继发于胰高血糖素的释放，并且催产素对胰高血糖素以及可能对胰岛素分泌具有直接刺激作用。
