Altszuler N, Hampshire J
Proc Soc Exp Biol Med. 1981 Oct;168(1):123-4. doi: 10.3181/00379727-168-41245.
Intravenously administered oxytocin was found to increase plasma insulin and glucagon levels. To explore if the same effects could be obtained by nonparenteral routes of administration, oxytocin was given by nasal instillation in normal conscious dogs. Plasma glucose, insulin, and glucagon levels all increased to levels which previously were shown to cause increased glucose production and utilization. Vasopressin infusion had no effect on these measurements. This is the first report of the effectiveness of oxytocin to evoke insulin and glucagon secretion by the nasal route of administration.
静脉注射催产素可使血浆胰岛素和胰高血糖素水平升高。为探究通过非肠道给药途径是否能获得相同效果，对正常清醒犬经鼻腔滴注催产素。血浆葡萄糖、胰岛素和胰高血糖素水平均升高至先前显示可导致葡萄糖生成和利用增加的水平。输注加压素对这些测量值无影响。这是关于催产素经鼻腔给药途径诱发胰岛素和胰高血糖素分泌有效性的首篇报道。
