Le Chi Chip, Wismer Michael K, Shi Zhi-Cai, Zhang Rui, Conway Donald V, Li Guoqing, Vachal Petr, Davies Ian W, MacMillan David W C
Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.
Discovery Chemistry and Process Research & Development, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
ACS Cent Sci. 2017 Jun 28;3(6):647-653. doi: 10.1021/acscentsci.7b00159. Epub 2017 May 17.
Photocatalysis for organic synthesis has experienced an exponential growth in the past 10 years. However, the variety of experimental procedures that have been reported to perform photon-based catalyst excitation has hampered the establishment of general protocols to convert visible light into chemical energy. To address this issue, we have designed an integrated photoreactor for enhanced photon capture and catalyst excitation. Moreover, the evaluation of this new reactor in eight photocatalytic transformations that are widely employed in medicinal chemistry settings has confirmed significant performance advantages of this optimized design while enabling a standardized protocol.
在过去十年中，用于有机合成的光催化技术呈指数级增长。然而，据报道，用于进行基于光子的催化剂激发的各种实验程序阻碍了将可见光转化为化学能的通用方案的建立。为了解决这个问题，我们设计了一种集成光反应器，以增强光子捕获和催化剂激发。此外，在药物化学环境中广泛使用的八种光催化转化中对这种新型反应器的评估证实了这种优化设计的显著性能优势，同时实现了标准化方案。
