通过σ重排将羟胺用作化学选择性（邻位-氨基）芳基化试剂。
Hydroxamic Acids as Chemoselective (ortho-Amino)arylation Reagents via Sigmatropic Rearrangement.
机构信息
Institute of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090, Wien, Austria.
Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua, 321004, China.
出版信息
Angew Chem Int Ed Engl. 2017 Aug 28;56(36):10938-10941. doi: 10.1002/anie.201703667. Epub 2017 Aug 2.
PMID:28691189
Abstract
The use of readily available hydroxamic acids as reagents for the chemoselective (ortho-amino)arylation of amides is described. This reaction proceeds under metal-free, mild conditions, displays a very broad scope, and constitutes a direct approach for the metal-free attachment of aniline residues to carbonyl derivatives.
摘要
本文描述了将易得的羟胺类化合物作为试剂，用于酰胺的化学选择性（邻位-氨基）芳基化反应。该反应在无金属、温和条件下进行，具有很广泛的适用范围，是一种将苯胺残基直接连接到羰基衍生物上的无金属方法。
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