猫胃非肾上腺素能、非胆碱能神经支配的脑啡肽能假说的体外研究。

In-vitro study of the enkephalinergic hypothesis for non-adrenergic, non-cholinergic innervation in the cat stomach.

作者信息

Lefebvre R A, Bogaert M G, De Schaepdryver A F

出版信息

J Pharm Pharmacol. 1986 Jan;38(1):35-9. doi: 10.1111/j.2042-7158.1986.tb04463.x.

DOI:10.1111/j.2042-7158.1986.tb04463.x

Abstract

It has been suggested that enkephalins are involved in the gastric relaxation induced by stimulation of the non-adrenergic, non-cholinergic vagal fibres in the cat stomach. Experiments were therefore performed on strips of cat stomach. With longitudinal and circular gastric fundus and corpus strips from reserpinized cats, non-adrenergic, non-cholinergic relaxatory responses could be elicited by transmural electrical stimulation in Tyrode solution containing atropine and 5-hydroxytryptamine. Morphine, leu-enkephalin and met-enkephalin did not influence the tone of the strips or the relaxation evoked by stimulation at 8 Hz, and neither did the opioid antagonist, naloxone. These results do not support the enkephalinergic hypothesis for the non-adrenergic, non-cholinergic vagal fibres in the cat stomach.

摘要

有人提出脑啡肽参与了猫胃中刺激非肾上腺素能、非胆碱能迷走神经纤维所引起的胃舒张。因此，在猫胃条上进行了实验。用利血平化猫的胃底和胃体纵行及环形条，在含阿托品和5-羟色胺的台氏液中，经壁电刺激可诱发非肾上腺素能、非胆碱能舒张反应。吗啡、亮氨酸脑啡肽和甲硫氨酸脑啡肽不影响条的张力或8赫兹刺激所诱发的舒张，阿片拮抗剂纳洛酮也无此作用。这些结果不支持猫胃中非肾上腺素能、非胆碱能迷走神经纤维的脑啡肽能假说。