Choromańska Barbara, Myśliwiec Piotr, Choromańska Katarzyna, Dadan Jacek, Chabowski Adrian
1st Department of General and Endocrine Surgery, Medical University of Bialystok, Poland.
SKN Dental Biochemistry at the Department of Conservative Dentistry, Medical University of Bialystok, Poland.
Adv Clin Exp Med. 2017 Jul;26(4):717-722. doi: 10.17219/acem/62325.
Atherosclerosis is a progressive, chronic inflammation in artery walls. Oxidized low density lipoproteins (ox-LDL) play an important role in atherosclerotic plaque formation. ox-LDL are taken up by macrophages mainly through scavenger receptors, among which CD36 is considered to be the most important. Animal studies have shown that crossing atherogenic mice with a strain lacking the expression of CD36 prevented the development of atherosclerosis despite a diet rich in saturated LCFA. In humans, autopsy studies performed in obese patients have demonstrated increased expression of CD36 receptor on macrophages, comprised within atherosclerotic plaques. Until recently it had been believed that CD36 is a major player in atherosclerosis progression in humans. However, recent studies challenge this conviction, showing increased incidence of coronary heart disease in the subgroup of patients with decreased expression of CD36. This article reviews the role of CD36 receptor in the development of atherosclerosis. The authors also discuss current possibilities to interfere with CD36, their potential benefits and hazards.
动脉粥样硬化是一种发生于动脉壁的进行性慢性炎症。氧化型低密度脂蛋白（ox-LDL）在动脉粥样硬化斑块形成中起重要作用。ox-LDL主要通过清道夫受体被巨噬细胞摄取，其中CD36被认为是最重要的。动物研究表明，将致动脉粥样硬化小鼠与缺乏CD36表达的品系杂交，尽管给予富含饱和长链脂肪酸（LCFA）的饮食，仍可预防动脉粥样硬化的发展。在人类中，对肥胖患者进行的尸检研究表明，动脉粥样硬化斑块内的巨噬细胞上CD36受体的表达增加。直到最近，人们一直认为CD36是人类动脉粥样硬化进展的主要参与者。然而，最近的研究对这一观点提出了挑战，研究显示CD36表达降低的患者亚组中冠心病的发病率增加。本文综述了CD36受体在动脉粥样硬化发展中的作用。作者还讨论了目前干扰CD36的可能性、其潜在益处和危害。
