Brain-Behaviour Research Group, University of New England, Armidale, Australia.
Genesiscare, Tugun, Queensland and Brain-Behaviour Research Group, University of New England, Armidale, New South Wales, Australia.
Psychooncology. 2018 Jan;27(1):223-228. doi: 10.1002/pon.4496. Epub 2017 Aug 1.
To investigate the effect of chronic stress as measured in cortisol concentrations upon the association between psychological resilience (PR) and depression in prostate cancer (PCa) patients.
A total of 104 men with PCa completed inventories on PR, depression, and background factors, plus gave a sample of their saliva for cortisol assay.
The inverse correlation between PR and depression was present only for PCa patients with low or moderate concentrations of salivary cortisol (when classified as more than 1.0 SD below the mean vs within 1.0 SD of the group mean) but not for those men whose cortisol was >1.0 SD from the group mean. Specific PR factors and behaviours that made the greatest contribution to depression were identified for the low and moderate cortisol groups.
These results suggest that there are particular aspects of PR that are most strongly related to depression, but that PR's inverse association with depression may be absent in participants with extreme chronic physiological stress.
探讨皮质醇浓度所衡量的慢性应激对前列腺癌（PCa）患者心理弹性（PR）与抑郁之间关联的影响。
共有 104 名男性 PCa 患者完成了 PR、抑郁和背景因素的问卷，并提供了唾液皮质醇检测样本。
只有皮质醇唾液浓度低或中等的 PCa 患者的 PR 和抑郁之间呈负相关（当被分类为低于平均值 1.0 个标准差以上与在平均值 1.0 个标准差内相比），而皮质醇高于平均值 1.0 个标准差的男性则没有。对于皮质醇水平较低和中等的患者，确定了对抑郁影响最大的特定 PR 因素和行为。
这些结果表明，PR 与抑郁之间存在特定的关联，但在经历极度慢性生理应激的参与者中，PR 与抑郁之间的负相关可能不存在。
