a Department of Cardiology , Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases , Beijing , China.
b Department of Hypertension Research , Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases , Beijing , China.
Clin Exp Hypertens. 2017;39(6):562-569. doi: 10.1080/10641963.2017.1291660. Epub 2017 Jul 10.
No consensus view has been published on the relationship between the aldosterone synthase gene (CYP11B2) -344C/T polymorphism and left ventricular hypertrophy (LVH) in Chinese Han. We undertook a meta-analysis to investigate the potential association of this polymorphism and left ventricular structure-related phenotypes, including left ventricular mass (LVM), left ventricular mass index (LVMI), left ventricular end systolic diameter (LVESD), left ventricular end diastolic dimension (LVEDD), left ventricular posterior wall thickness (LVPWT), and interventricular septal wall thickness (IVS). Studies in English and Chinese were found based on a systematic search of Medline, Embase, CNKI, and Wanfang databases. The dominant model (TT vs. TC+CC) and homozygote model (TT vs. CC) were selected to examine the association between the -344C/T polymorphism and LVH. The random-effects model was used to pool data. From a total of 3104 participants, despite the investigation of six echocardiographic indicators, we found no significant association between the -344C/T variant and LVH in the whole group and the subgroup analyses by blood pressure. However, in the subgroup of northern Han Chinese, TT genotype had higher LVPWT than CC genotype and TC genotype (p = 0.4, p = 0.04, 95% CI 0.09 (0.00, 0.18)). In addition, no evidence of publication bias was observed. In conclusion, our meta-analysis indicated that subjects with TT genotype might have higher risk of developing LVH in northern Han Chinese.
尚未发表关于中国人醛固酮合酶基因 (CYP11B2) -344C/T 多态性与左心室肥厚 (LVH) 之间关系的共识意见。我们进行了一项荟萃分析，以调查这种多态性与左心室结构相关表型之间的潜在关联，包括左心室质量 (LVM)、左心室质量指数 (LVMI)、左心室收缩末期直径 (LVESD)、左心室舒张末期直径 (LVEDD)、左心室后壁厚度 (LVPWT) 和室间隔壁厚度 (IVS)。基于对 Medline、Embase、CNKI 和万方数据库的系统搜索，发现了英文和中文研究。选择显性模型 (TT 与 TC+CC) 和纯合子模型 (TT 与 CC) 来检验 -344C/T 多态性与 LVH 之间的关系。使用随机效应模型对数据进行合并。从总共 3104 名参与者中，尽管调查了 6 项超声心动图指标，但我们没有发现 -344C/T 变异与整个组和按血压分组的 LVH 之间存在显著关联。然而，在北方汉族亚组中，TT 基因型的 LVPWT 高于 CC 基因型和 TC 基因型 (p = 0.4，p = 0.04，95%CI 0.09 (0.00，0.18))。此外，没有发现发表偏倚的证据。总之，我们的荟萃分析表明，TT 基因型的受试者在北方汉族人群中可能有更高的发生 LVH 的风险。
