Department of Cardiology, Second Affiliated Hospital, Nanchang University, Nanchang, PR China.
Kidney Blood Press Res. 2009;32(2):128-40. doi: 10.1159/000215738. Epub 2009 Apr 30.
A thymidine-to-cytosine substitution in the -344 promoter region of the aldosterone synthase gene (CYP11B2) has been associated with essential hypertension in some but not all studies conducted in Chinese. We performed a meta-analysis to evaluate the association of the -344C/T polymorphism with essential hypertension in Chinese. A total of 7,472 individuals (4,259 unselected hypertensive patients and 3,213 normotensive controls) from 9 case-control studies were included in the present investigation. Significant associations between the risk of hypertension and the CC genotype and C allele frequencies were found in a total of 19 studies. Our findings support the notion that the CYP11B2 -344C/T polymorphism is associated with essential hypertension. In addition, C allele frequency was found to be lower in southern Chinese controls than in their northern counterparts, and the higher TT genotype homozygous frequency in the southern Chinese supports the hypothesis that the northern Chinese are of southern origin.
醛固酮合酶基因（CYP11B2）-344 启动子区域的胸腺嘧啶到胞嘧啶取代与中国的一些但不是所有研究中的原发性高血压有关。我们进行了荟萃分析，以评估-344C/T 多态性与中国人原发性高血压的关系。本研究共纳入了 9 项病例对照研究中的 7472 名个体（4259 名未经选择的高血压患者和 3213 名正常血压对照者）。在总共 19 项研究中发现，高血压风险与 CC 基因型和 C 等位基因频率之间存在显著相关性。我们的研究结果支持 CYP11B2-344C/T 多态性与原发性高血压相关的观点。此外，还发现南方中国对照组的 C 等位基因频率低于北方对照组，南方中国人中 TT 基因型纯合子频率较高，支持北方中国人起源于南方的假说。
