Pfau Maximilian, Lindner Moritz, Müller Philipp L, Birtel Johannes, Finger Robert P, Harmening Wolf M, Fleckenstein Monika, Holz Frank G, Schmitz-Valckenberg Steffen
Department of Ophthalmology, University of Bonn, Bonn, Germany.
Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO158-BIO167. doi: 10.1167/iovs.17-21454.
To determine the effective dynamic range (EDR), retest reliability, and number of discriminable steps (DS) for mesopic and dark-adapted two-color fundus-controlled perimetry (FCP) using the S-MAIA (Scotopic-Macular Integrity Assessment) "micro-perimeter."
In this prospective cross-sectional study, each of the 52 eyes of 52 subjects with various macular diseases (mean age 62.0 ± 16.9 years; range, 19.1-90.1 years) underwent duplicate mesopic (achromatic stimuli, 400-800 nm), dark-adapted cyan (505 nm), and dark-adapted red (627 nm) FCP using a grid of 61 stimuli covering 18° of the central retina. The EDR, the number of DS, and the retest reliability for point-wise sensitivity (PWS) were analyzed. The effects of fixation stability, sensitivity, and age on retest reliability were examined using mixed-effects models.
The EDR was 10 to 30 dB with five DS for mesopic and 4 to 17 dB with four DS for dark-adapted cyan and red testing. PWS retest reliability was good among all three types of retinal sensitivity assessments (coefficient of repeatability ±5.79, ±4.72, and ±4.77 dB, respectively) and did not depend on fixation stability or age. PWS had no effect on retest variability in dark-adapted cyan and dark-adapted red testing but had a minor effect in mesopic testing.
Combined mesopic and dark-adapted two-color FCP allows for reliable topographic testing of cone and rod function in patients with various macular diseases with and without foveal fixation. Retest reliability is homogeneous across eccentricities and various degrees of scotoma depth, including zones at risk for disease progression. These reliability estimates can serve for the design of future clinical trials.
使用S-MAIA（暗视-黄斑完整性评估）“微视野计”确定中视和暗适应双色眼底控制视野检查（FCP）的有效动态范围（EDR）、重测可靠性和可分辨步骤数（DS）。
在这项前瞻性横断面研究中，52名患有各种黄斑疾病的受试者（平均年龄62.0±16.9岁；范围19.1 - 90.1岁）的52只眼睛，每只眼睛都使用覆盖中央视网膜18°的61个刺激点网格进行了重复的中视（消色差刺激，400 - 800 nm）、暗适应蓝绿色（505 nm）和暗适应红色（627 nm）FCP检查。分析了EDR、DS数量和逐点敏感度（PWS）的重测可靠性。使用混合效应模型检查了注视稳定性、敏感度和年龄对重测可靠性的影响。
中视检查的EDR为10至30 dB，有5个DS；暗适应蓝绿色和红色检查的EDR为4至17 dB，有4个DS。在所有三种类型的视网膜敏感度评估中，PWS重测可靠性良好（重复性系数分别为±5.79、±4.72和±4.77 dB），且不依赖于注视稳定性或年龄。PWS对暗适应蓝绿色和暗适应红色检查中的重测变异性没有影响，但在中视检查中有轻微影响。
联合中视和暗适应双色FCP能够对患有和未患有黄斑中心凹注视的各种黄斑疾病患者的视锥和视杆功能进行可靠的地形图检查。重测可靠性在不同偏心度和不同程度的暗点深度（包括疾病进展风险区域）中是一致的。这些可靠性估计可用于未来临床试验的设计。
