Lee Jun Ho, Byun Min Soo, Yi Dahyun, Choe Young Min, Choi Hyo Jung, Baek Hyewon, Sohn Bo Kyung, Lee Jun-Young, Kim Hyun Jung, Kim Jee Wook, Lee Younghwa, Kim Yu Kyeong, Sohn Chul-Ho, Woo Jong Inn, Lee Dong Young
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea.
Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea.
Neurobiol Aging. 2017 Oct;58:34-40. doi: 10.1016/j.neurobiolaging.2017.06.005. Epub 2017 Jun 19.
This study aimed to examine the sex-specific association between serum sex hormones and gonadotropins and the cerebral beta-amyloid (Aβ) burden and hippocampal neurodegeneration in subjects with normal cognition and impaired cognition. Two hundred sixty-five older subjects received clinical assessments, serum measurements of sex hormones, gonadotropins, C-Pittsburgh compound B-positron emission tomography, and magnetic resonance imaging. In females, higher free testosterone and gonadotropin levels were associated with lower cerebral Aβ positivity. In males, free testosterone was positively related to hippocampal volume with significant interaction with cognitive status. Further subgroup analyses showed that the association was significant only in impaired cognition but not in normal cognition. Free estradiol was not associated with Aβ burden or hippocampal neurodegeneration in either sex. These results suggest that testosterone might inhibit the early pathological accumulation of Aβ in females and delay neurodegeneration in males.
本研究旨在探讨血清性激素和促性腺激素与认知正常及认知受损受试者脑内β-淀粉样蛋白（Aβ）负荷及海马神经退行性变之间的性别特异性关联。265名老年受试者接受了临床评估、血清性激素、促性腺激素检测、C-匹兹堡化合物B正电子发射断层扫描及磁共振成像检查。在女性中，较高的游离睾酮和促性腺激素水平与较低的脑Aβ阳性率相关。在男性中，游离睾酮与海马体积呈正相关，且与认知状态存在显著交互作用。进一步的亚组分析表明，这种关联仅在认知受损者中显著，在认知正常者中不显著。游离雌二醇与两性的Aβ负荷或海马神经退行性变均无关联。这些结果表明，睾酮可能抑制女性Aβ的早期病理积累，并延缓男性的神经退行性变。
