Department of Endocrinology, Diabetes and Isotope Therapy, University Clinical Hospital, 50-367 Wroclaw, Poland.
Endocrinological Ambulatory Care, 62-700 Turek, Poland.
Biomolecules. 2024 Jul 28;14(8):918. doi: 10.3390/biom14080918.
Alzheimer disease, the leading cause of dementia, and polycystic ovary syndrome, one of the most prevalent female endocrine disorders, appear to be unrelated conditions. However, studies show that both disease entities have common risk factors, and the amount of certain protein marker of neurodegeneration is increased in PCOS. Reports on the pathomechanism of both diseases point to the possibility of common denominators linking them. Dysregulation of the kynurenine pathway, insulin resistance, and impairment of the hypothalamic-pituitary-gonadal axis, which are correlated with amyloid-beta aggregation are these common areas. This article discusses the relationship between Alzheimer disease and polycystic ovary syndrome, with a particular focus on the role of disorders of tryptophan metabolism in both conditions. Based on a review of the available literature, we concluded that systemic changes occurring in PCOS influence the increased risk of neurodegeneration.
阿尔茨海默病是痴呆症的主要病因，多囊卵巢综合征是最常见的女性内分泌疾病之一，两者似乎没有关联。然而，研究表明这两种疾病都有共同的风险因素，而且多囊卵巢综合征患者的某些神经退行性病变的蛋白标志物的含量增加。关于这两种疾病的发病机制的报告指出，它们可能存在共同的联系。色氨酸代谢紊乱、胰岛素抵抗以及与淀粉样蛋白-β聚集相关的下丘脑-垂体-性腺轴功能障碍是这些共同的领域。本文讨论了阿尔茨海默病和多囊卵巢综合征之间的关系，特别关注了两种疾病中色氨酸代谢紊乱的作用。通过对现有文献的回顾，我们得出结论，多囊卵巢综合征中发生的全身变化会影响神经退行性病变风险的增加。
