Kushnir Vladyslav, Sproule Beth A, Cunningham John A
Centre for Addiction and Mental Health, 33 Russell St, Toronto, Ontario, M5S 2S1, Canada.
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, M5S 3M2, Canada.
BMC Public Health. 2017 Jul 11;18(1):4. doi: 10.1186/s12889-017-4548-5.
Large-scale distribution efforts of free nicotine replacement therapy (NRT) have been documented to be cost-effective interventions for increasing smoking quit rates. However, despite nearly a dozen studies evaluating their effectiveness, none have examined whether free NRT provision promotes further primary care help-seeking and the impact that it may have on cessation efforts.
In the context of a randomized controlled trial, a secondary analysis was conducted on 1000 adult regular smokers randomized to be mailed a 5-week supply of nicotine patches or to a no intervention control group. Recipients and users of free nicotine patches at an 8 week follow-up were successfully case matched to controls based on age, gender, baseline level of nicotine dependence and intent to quit (n = 201 per group). Differences in physician interaction between the two groups were evaluated at both 8 week and 6 month follow-ups. The impact of physician interaction on self-reported smoking abstinence at each follow-up was also examined.
Although no differences in physician interaction were noted between groups at the 8 week follow-up, at the 6 month follow-up, nicotine patch users reported greater frequency of discussing smoking with their physician (43.9%), as compared to the control group (30.3%) (p = 0.011). Across both groups, over 90% of those that discussed smoking with a physician were encouraged to quit and approximately 70% were provided with additional support. Separate ANOVAs revealed no significant impact of physician interaction on cessation (p > 0.05), regardless of group or follow-up period, however, at the 6 month follow-up, nicotine patch users who discussed cessation with a physician had made serious quit attempts at significantly greater rates (72.6%), compared to controls (49.1%) (p = 0.007).
Irrespective of group, the majority of smokers in the present study did not discuss cessation with their physician. Recipients and users of nicotine patches however, were more likely to discuss smoking with their physician, suggesting that the provision of free NRT particularly to those who are likely to use it may facilitate opportunities for benefits beyond the direct pharmacological effects of the medication.
clinicaltrials.gov , NCT01429129 . Registered: 2 September 2011.
大规模发放免费尼古丁替代疗法(NRT)已被证明是提高戒烟率的具有成本效益的干预措施。然而,尽管有近十几项研究评估了其有效性,但尚无研究考察免费提供NRT是否能促进更多人寻求初级保健帮助以及它可能对戒烟努力产生的影响。
在一项随机对照试验的背景下,对1000名成年规律吸烟者进行了二次分析,这些吸烟者被随机分为两组,一组邮寄为期5周的尼古丁贴片,另一组为无干预对照组。在8周随访时,成功地根据年龄、性别、尼古丁依赖基线水平和戒烟意愿将免费尼古丁贴片的接受者和使用者与对照组进行病例匹配(每组n = 201)。在8周和6个月随访时评估两组之间医生互动的差异。还考察了每次随访时医生互动对自我报告戒烟情况的影响。
虽然在8周随访时两组之间未发现医生互动有差异,但在6个月随访时,尼古丁贴片使用者报告与医生讨论吸烟的频率更高(43.9%),而对照组为(30.3%)(p = 0.011)。在两组中,超过90%与医生讨论吸烟的人被鼓励戒烟,约70%的人得到了额外支持。单独的方差分析显示,无论组别或随访期如何,医生互动对戒烟均无显著影响(p>0.05),然而,在6个月随访时,与医生讨论戒烟的尼古丁贴片使用者进行认真戒烟尝试的比例显著更高(72.6%),而对照组为(49.1%)(p = 0.007)。
无论组别如何,本研究中的大多数吸烟者未与医生讨论戒烟。然而,尼古丁贴片的接受者和使用者更有可能与医生讨论吸烟,这表明免费提供NRT,特别是向可能使用它的人提供,可能会促进获得除药物直接药理作用之外的益处的机会。
clinicaltrials.gov,NCT01429129。注册时间:2011年9月2日。