Kushnir Vladyslav, Sproule Beth A, Cunningham John A
Centre for Addiction and Mental Health, Toronto M5S 2S1, Canada; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto M5S 3M2, Canada.
Centre for Addiction and Mental Health, Toronto M5S 2S1, Canada; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto M5S 3M2, Canada.
Addict Behav. 2017 Apr;67:73-78. doi: 10.1016/j.addbeh.2016.12.008. Epub 2016 Dec 23.
There is growing evidence that the mailed distribution of free nicotine replacement therapy (NRT), usually as part of smokers' helplines, can been effective in increasing the odds of cessation on a population level. However, limited information is available on the utilization of NRT when it is provided for free, and factors associated with regimen adherence have remained largely unexplored.
In the context of a randomized controlled trial, 500 adult smokers across Canada hypothetically interested in free NRT were mailed a 5week supply of nicotine patches, but no other support was offered. Analyses evaluated which a priori-defined demographic and smoking characteristics predicted nicotine patch use at 8week follow-up of 421 patch recipients, as well as examined the association between patch use and smoking cessation at 6months.
At 8weeks, 10.9% had used all, 47.5% had used some but not all, and 41.6% had not used any of the provided nicotine patches. Lower age, unemployment, past NRT use and intent to quit in the next 30days at baseline (preparation stage of change) were all identified as independent predictors of some nicotine patch use. Only use of all patches was associated with greater odds of smoking cessation, compared to non-users (Adj. OR=2.96; 95%CI=1.06-8.27).
The mailed distribution of free nicotine patches to smokers at large can be effective at promoting cessation, particularly among financially disadvantaged groups, those with previous NRT experience and among individuals with already advanced intent to quit.
越来越多的证据表明，通常作为吸烟者帮助热线一部分的免费尼古丁替代疗法（NRT）邮寄分发，在提高人群戒烟几率方面可能是有效的。然而，关于免费提供NRT的使用情况以及与治疗方案依从性相关的因素，目前所知有限。
在一项随机对照试验中，向加拿大500名假设对免费NRT感兴趣的成年吸烟者邮寄了为期5周的尼古丁贴片供应，但未提供其他支持。分析评估了哪些预先定义的人口统计学和吸烟特征能够预测421名贴片接受者在8周随访时对尼古丁贴片的使用情况，并研究了贴片使用与6个月时戒烟之间的关联。
在8周时，10.9%的人用完了所有贴片，47.5%的人使用了部分但并非全部贴片，41.6%的人未使用任何提供的尼古丁贴片。年龄较小、失业、既往使用过NRT以及在基线时（改变的准备阶段）打算在未来30天内戒烟，均被确定为使用部分尼古丁贴片的独立预测因素。与未使用者相比，仅使用完所有贴片与更高的戒烟几率相关（调整后的比值比=2.96；95%置信区间=1.06 - 8.27）。
向广大吸烟者邮寄免费尼古丁贴片在促进戒烟方面可能是有效的，特别是在经济弱势群体、有过NRT使用经验的人群以及已有强烈戒烟意愿的个体中。
