Department of Biochemistry, Faculty of Technical and Natural Sciences III, Saarland University, 66123 Saarbrücken, Germany; Institute of Biochemistry, Campus B2.2, Saarland University, D-66123 Saarbrücken, Germany.
Department of Biochemistry, Faculty of Technical and Natural Sciences III, Saarland University, 66123 Saarbrücken, Germany; Institute of Biochemistry, Campus B2.2, Saarland University, D-66123 Saarbrücken, Germany.
J Steroid Biochem Mol Biol. 2018 May;179:3-7. doi: 10.1016/j.jsbmb.2017.07.004. Epub 2017 Jul 8.
In the last decades, sulfonated steroids evolved from inactive metabolites intended for excretion to highly relevant compounds involved in many physiological processes. Investigations of the impact of sulfonated steroids on the steroid hormone biosynthesis revealed that, on the one hand, these can serve as substrate for steroidogenic cytochromes P450 and, on the other hand, these are able to influence the catalytic properties of these enzymes. In this review the relevance of sulfonated steroids for the steroid hormone biosynthesis will be discussed.
在过去的几十年中，磺化甾体已经从旨在排泄的无活性代谢物演变为参与许多生理过程的重要化合物。磺化甾体对甾体激素生物合成影响的研究表明，一方面，它们可以作为甾体生成细胞色素 P450 的底物，另一方面，它们能够影响这些酶的催化特性。本文将讨论磺化甾体对甾体激素生物合成的重要性。
