氨基酸神经递质候选物对一种已鉴定的昆虫运动神经元的影响。

Effects of amino acid neurotransmitter candidates on an identified insect motoneurone.

作者信息

Wafford K A, Sattelle D B

出版信息

Neurosci Lett. 1986 Jan 16;63(2):135-40. doi: 10.1016/0304-3940(86)90050-9.

Abstract

The cell body of the fast coxal depressor motoneurone (Df) was used to examine the effects of a group of putative amino acid neurotransmitters. gamma-Aminobutyric acid (GABA) elicited a biphasic hyperpolarizing response, each component having a separate reversal potential. Both components were affected by the GABA antagonist picrotoxinin. L-Glutamate produced a hyperpolarizing response with a reversal potential of between -80 and -85 mV, and L-aspartate gave a similar but less potent effect. Kainic acid and quisqualic acid elicited depolarizing responses of up to 10 mV in amplitude. beta-Alanine and taurine produced a single hyperpolarization with a reversal potential similar to glutamate. Glycine was ineffective on motoneurone Df.

摘要

快速髋部下压运动神经元（Df）的细胞体被用于研究一组假定的氨基酸神经递质的作用。γ-氨基丁酸（GABA）引发双相超极化反应，每个成分都有一个单独的反转电位。两个成分都受到GABA拮抗剂印防己毒素的影响。L-谷氨酸产生超极化反应，反转电位在-80至-85 mV之间，L-天冬氨酸产生类似但效力较弱的效果。 kainic酸和quisqualic酸引发幅度高达10 mV的去极化反应。β-丙氨酸和牛磺酸产生单一超极化，反转电位与谷氨酸相似。甘氨酸对运动神经元Df无效。