Iwama T, Ishihara K, Satoh M, Takagi H
Neurosci Lett. 1986 Jan 16;63(2):190-4. doi: 10.1016/0304-3940(86)90060-1.
We investigated the effects of dynorphin A (Dyn A), a heptadecapeptide, on the population spikes of the guinea pig hippocampal CA3 pyramidal neurons, in vitro, using paired-pulse stimulation of the mossy fibers. Dyn A produced facilitatory and inhibitory effects on the population spikes in the preparations with lower and higher degrees of paired-pulse facilitation, respectively. Morphine and D-Ala2, D-Leu5-en-kephalin, mu- and delta-agonist, respectively, predominantly potentiated the population spikes, while kappa-agonists such as U-50, 488H and bremazocine mainly caused an inhibition. These results suggest that Dyn A has two separate (excitatory and inhibitory) effects on the guinea pig hippocampal CA3 neurons through mu-(delta) and kappa-opioid receptors, respectively.
我们在体外使用苔藓纤维的双脉冲刺激，研究了十七肽强啡肽A（Dyn A）对豚鼠海马CA3锥体神经元群体峰电位的影响。Dyn A分别对双脉冲易化程度较低和较高的标本中的群体峰电位产生易化和抑制作用。吗啡和D-Ala2，D-Leu5-脑啡肽，分别为μ和δ激动剂，主要增强群体峰电位，而κ激动剂如U-50、488H和布马佐辛主要引起抑制作用。这些结果表明，Dyn A分别通过μ（δ）和κ阿片受体对豚鼠海马CA3神经元有两种独立的（兴奋性和抑制性）作用。
