De Montis G M, Devoto P, Preti A, Tagliamonte A
J Neurosci Res. 1987;17(4):435-9. doi: 10.1002/jnr.490170416.
D-Ala2, D-Leu5-enkephalin (DADLE) and dynorphin1-13 (Dyn1-13) inhibited striatal adenylate cyclase activity, both basal and dopamine-stimulated (DA), in rats and guinea pigs. The kappa-agonists bremazocine (BRZ), U-50,488 (trans-3,4-dicloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide), and U-69,593 (5 alpha, 7 alpha 8 beta)-(-)-N-methyl-N-(7-(1-pyrrolidinyl-1-oxaspiro (4.5)dec-8yl) benzeneacetamide inhibited only the basal adenylate cyclase activity, and such an effect was restricted to guinea pig striatum, an area known to contain a high density of kappa-binding sites. Moreover, BRZ was found to antagonize the inhibitory effect of both DADLE and Dyn1-13 in rat striatum.
D-丙氨酸2、D-亮氨酸5-脑啡肽（DADLE）和强啡肽1-13（Dyn1-13）抑制大鼠和豚鼠纹状体腺苷酸环化酶活性，包括基础活性和多巴胺刺激的活性。κ激动剂布马佐辛（BRZ）、U-50,488（反式-3,4-二氯-N-甲基-N-[2-(1-吡咯烷基)-环己基]-苯乙酰胺）和U-69,593（5α,7α,8β）-（-）-N-甲基-N-（7-(1-吡咯烷基-1-氧杂螺(4.5)癸-8基）苯乙酰胺仅抑制基础腺苷酸环化酶活性，且这种作用仅限于豚鼠纹状体，该区域已知含有高密度的κ结合位点。此外，发现BRZ可拮抗DADLE和Dyn1-13对大鼠纹状体的抑制作用。
