Xiang Yan, Li Zhi-Xiao, Zhang Ding-Yu, He Zhi-Gang, Hu Ji, Xiang Hong-Bing
Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, Hubei, China.
Department of Anesthesiology and Pain Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and TechnologyWuhan 430030, Hubei, PR China.
Int J Physiol Pathophysiol Pharmacol. 2017 Jun 15;9(3):64-68. eCollection 2017.
It is important to realize that characterization of the circadian rhythm patterns of seizure occurrence can implicate in diagnosis and treatment of selected types of epilepsy. Evidence suggests a role for the suprachiasmatic nucleus (SCN) circuits in overall circadian rhythm and seizure susceptibility both in animals and humans. Thus, we conclude that SCN circuits may exert modifying effects on circadian rhythmicity and neuronal excitability during epileptogenesis. SCN circuits will be studied in our brain centre and collaborating centres to explore further the interaction between the circadian rhythm and epileptic seizures. More and thorough research is warranted to provide insight into epileptic seizures with circadian disruption comorbidities such as disorders of cardiovascular parameters and core body temperature circadian rhythms.
重要的是要认识到，癫痫发作昼夜节律模式的特征可能对某些类型癫痫的诊断和治疗具有启示意义。有证据表明，在动物和人类中，视交叉上核（SCN）回路在整体昼夜节律和癫痫易感性方面均发挥作用。因此，我们得出结论，SCN回路可能在癫痫发生过程中对昼夜节律性和神经元兴奋性产生调节作用。我们的脑中心和合作中心将对视交叉上核回路进行研究，以进一步探索昼夜节律与癫痫发作之间的相互作用。有必要进行更深入、更全面的研究，以深入了解伴有昼夜节律紊乱合并症（如心血管参数紊乱和核心体温昼夜节律紊乱）的癫痫发作。
