El Osta Rabih, Grandpre Nicolas, Monnin Nicolas, Hubert Jacques, Koscinski Isabelle
Urology Department of Brabois University Hospital, CHU Nancy, Vandœuvre-lès-Nancy, France.
Hematology department, CHRU Strasbourg, Strasbourg, France.
Basic Clin Androl. 2017 Jul 8;27:13. doi: 10.1186/s12610-017-0057-8. eCollection 2017.
Hereditary hemochromatosis is a genetic disease that progresses silently. This disease is often diagnosed late when complications appear. Hypogonadotropic hypogonadism (HH) is one of the classical complications of hemochromatosis. Its frequency is declining probably because of earlier diagnosis and better informed physicians. Certain symptoms linked to HH can have an impact on a patient's sexuality, such as decreased libido, erectile dysfunction, and impairment of ejaculation, as well as on his reproductive capacities. This review is based on an online search in English, French and German language publications found in PubMed/Medline, up to 23 September 2016 using the following key word: Male infertility, Hypogonadotropic Hypogonadism, Hereditary Hemochromatosis. Thirty-four papers met these inclusion criteria. This review describes the impact of iron overload on male fertility, resulting in hypogonadotropic hypogonadism and proposes treatment modalities.
遗传性血色素沉着症是一种悄然发展的遗传疾病。这种疾病常在出现并发症时才被晚期诊断出来。低促性腺激素性性腺功能减退（HH）是血色素沉着症的经典并发症之一。其发病率可能因早期诊断和医生知识的更新而呈下降趋势。某些与HH相关的症状会对患者的性功能产生影响，如性欲减退、勃起功能障碍和射精障碍，以及对其生殖能力产生影响。本综述基于截至2016年9月23日在PubMed/Medline上搜索到的英文、法文和德文出版物进行在线检索，使用了以下关键词：男性不育、低促性腺激素性性腺功能减退、遗传性血色素沉着症。34篇论文符合这些纳入标准。本综述描述了铁过载对男性生育能力的影响，导致低促性腺激素性性腺功能减退，并提出了治疗方式。
