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纯合子Gunn大鼠乳鼠血浆非结合胆红素浓度与小脑胆红素含量之间的关系。

Relationship between plasma unbound-bilirubin concentration and cerebellar bilirubin content in homozygous Gunn rat sucklings.

作者信息

Sato H, Semba R

出版信息

Experientia. 1978 Feb 15;34(2):221-2. doi: 10.1007/BF01944689.

DOI:10.1007/BF01944689
PMID:564283
Abstract

Suckling increases and starvation (16 h) decreases plasma unbound-bilirubin concentration in 15-day-old homozygous Gunn rats. The effect of suckling-induced increase of plasma unbound-bilirubin concentration on cerebellar bilirubin content was examined. Cerebellar bilirubin content of the suckled rats did not increase, but rather decreased, in spite of the elevated concentration of plasma unbound-bilirubin . There were significant negative correlations between cerebellar bilirubin content and b. wt both in the suckled and starved groups.

摘要

在15日龄的纯合子冈恩大鼠中,哺乳会使血浆未结合胆红素浓度升高,而饥饿(16小时)则会使其降低。研究了哺乳引起的血浆未结合胆红素浓度升高对小脑胆红素含量的影响。尽管血浆未结合胆红素浓度升高,但哺乳大鼠的小脑胆红素含量并未增加,反而降低。在哺乳组和饥饿组中,小脑胆红素含量与体重均呈显著负相关。

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The serum levels of unbound bilirubin that induce changes in some brain mitochondrial reactions in newborn guinea-pigs.诱导新生豚鼠某些脑线粒体反应发生变化的未结合胆红素的血清水平。
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本文引用的文献

1
The dissociation of bilirubin from albumin and its clinical implications.胆红素与白蛋白的解离及其临床意义。
J Pediatr. 1959 Sep;55:268-79. doi: 10.1016/s0022-3476(59)80223-7.
2
Experimental bilirubin encephalopathy. The mode of entry of bilirubin-14C into the central nervous system.实验性胆红素脑病。胆红素-14C进入中枢神经系统的途径。
J Clin Invest. 1966 May;45(5):678-89. doi: 10.1172/JCI105383.
3
Binding and circular dichoism data on bilirubin-albumin in the presence of oleate and salicylate.在油酸盐和水杨酸盐存在的情况下胆红素 - 白蛋白的结合及圆二色性数据。
Arch Biochem Biophys. 1970 Sep;140(1):197-209. doi: 10.1016/0003-9861(70)90023-8.
4
Kernicterus: high incidence in premature infants with low serum bilirubin concentrations.核黄疸:血清胆红素浓度低的早产儿中发病率高。
Pediatrics. 1970 Jun;45(6):906-17.
5
Determination of unbound bilirubin in the serum of newborns.新生儿血清中游离胆红素的测定。
Clin Chem. 1974 Jul;20(7):783.
6
Bilirubin: a potent inhibitor of NAD+-linked isocitrate dehydrogenase.胆红素:一种NAD⁺连接的异柠檬酸脱氢酶的强效抑制剂。
Biochim Biophys Acta. 1973 Dec 19;327(2):233-7. doi: 10.1016/0005-2744(73)90405-1.
7
The use of critical levels of birth weight and "free bilirubin" as an approach for prevention of kernicterus.使用出生体重临界值和“游离胆红素”作为预防核黄疸的方法。
Biol Neonate. 1975;26(3-4):274-82. doi: 10.1159/000240739.
8
Effect of milk on plasma unbound-bilirubin concentration in homozygous Gunn rat sucklings.牛奶对纯合子冈恩大鼠乳鼠血浆非结合胆红素浓度的影响。
Experientia. 1977 Jan 15;33(1):59-61. doi: 10.1007/BF01936754.