Rosen J B, Young A M, Beuthin F C, Louis-Ferdinand R T
Pharmacol Biochem Behav. 1986 Feb;24(2):211-5. doi: 10.1016/0091-3057(86)90340-0.
The present study examined the discriminative stimulus properties of amphetamine (AMP) at progressively lower doses in lead-exposed and normal rats. In addition, generalization gradients of AMP, apomorphine, methylphenidate, and caffeine to both high and low training doses of AMP were determined in these rats. Under the high AMP training dose condition (1.0 mg/kg, IP) generalization gradients of AMP were similar for lead-exposed and control rats. When the training doses were progressively lowered, the lead-exposed rats tended to require a higher range of AMP doses (0.24-0.49 mg/kg) than did control rats (0.18-0.32 mg/kg) to maintain discriminative control. In parallel with this, the minimal discriminable doses tended to be higher for lead-exposed rats than for control rats. Methylphenidate generalization gradients were different for lead-exposed and control rats under the high AMP training condition but became similar under the low AMP training condition. No differences attributable to training dose or lead exposure were evident for apomorphine or caffeine.
本研究检测了在铅暴露大鼠和正常大鼠中，逐渐降低剂量的苯丙胺（AMP）的辨别刺激特性。此外，还测定了这些大鼠中AMP、阿扑吗啡、哌甲酯和咖啡因对高、低训练剂量AMP的泛化梯度。在高剂量AMP训练条件下（1.0毫克/千克，腹腔注射），铅暴露大鼠和对照大鼠的AMP泛化梯度相似。当训练剂量逐渐降低时，与对照大鼠（0.18 - 0.32毫克/千克）相比，铅暴露大鼠倾向于需要更高范围的AMP剂量（0.24 - 0.49毫克/千克）来维持辨别控制。与此同时，铅暴露大鼠的最小可辨别剂量往往高于对照大鼠。在高剂量AMP训练条件下，铅暴露大鼠和对照大鼠的哌甲酯泛化梯度不同，但在低剂量AMP训练条件下变得相似。阿扑吗啡或咖啡因在训练剂量或铅暴露方面没有明显差异。
