Daldrup-Link Heike
Department of Radiology, Lucile Packard Children's Hospital, and Pediatric Molecular Imaging Program (@PedsMIPS) in the Molecular Imaging Program at Stanford (MIPS), Stanford University.
Department of Pediatrics, Stanford University.
Curr Radiol Rep. 2017 Mar;5(3). doi: 10.1007/s40134-017-0207-y. Epub 2017 Feb 21.
To review how PET/MR technology could add value for pediatric cancer patients.
Since many primary tumors in children are evaluated with MRI and metastases are detected with PET/CT, integrated PET/MR can be a time-efficient and convenient solution for pediatric cancer staging. F-FDG PET/MR can assess primary tumors and the whole body in one imaging session, avoid repetitive anesthesia and reduce radiation exposure compared to F-FDG PET/CT. This article lists 10 action points, which might improve the clinical value of PET/MR for children with cancer. However, even if PET/MR proves valuable, it cannot enter mainstream applications if it is not accessible to the majority of pediatric cancer patients. Therefore, innovations are needed to make PET/MR scanners affordable and increase patient throughput.
PET/MR offers opportunities for more efficient, accurate and safe diagnoses of pediatric cancer patients. The impact on patient management and outcomes has to be substantiated by large-scale prospective clinical trials.
探讨正电子发射断层显像/磁共振成像（PET/MR）技术如何为儿童癌症患者增加价值。
由于许多儿童原发性肿瘤通过磁共振成像（MRI）进行评估，转移灶通过正电子发射断层显像/计算机断层扫描（PET/CT）进行检测，一体化PET/MR对于儿童癌症分期而言可能是一种高效且便捷的解决方案。与氟代脱氧葡萄糖（F-FDG）PET/CT相比，F-FDG PET/MR能够在一次成像检查中评估原发性肿瘤及全身情况，避免重复麻醉并减少辐射暴露。本文列出了10个要点，这些要点可能会提高PET/MR对儿童癌症患者的临床价值。然而，即便PET/MR被证明具有价值，但如果大多数儿童癌症患者无法使用，它也无法进入主流应用。因此，需要进行创新以使PET/MR扫描仪价格可承受并提高患者通量。
PET/MR为更高效、准确和安全地诊断儿童癌症患者提供了机会。其对患者管理及治疗结果的影响必须通过大规模前瞻性临床试验来证实。
