Enhancement of monomethylaminoantipyrine-induced increase of hepatic gamma-glutamyltranspeptidase activity by cobaltous chloride in rats.

Co-administration of MAA and CoCl2 enhanced the MAA-induced increase of hepatic microsomal gamma-GTP activity in rats. This may be explained by a fact that inhibition of MAA metabolism in hepatic microsomes by CoCl2 led to increase plasma concentration of MAA which, in turn, induction of gamma-GTP by MAA was potentiated.